I0500000

Isoniazid

European Pharmacopoeia (EP) Reference Standard

• Sinónimos: 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide
• Fórmula empírica (notación de Hill): C₆H₇N₃O
• Número de CAS: 54-85-3
• Peso molecular: 137.14
• Beilstein: 119374
• Número MDL: MFCD00006426
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329815311
• NACRES: NA.24

Propiedades

• grado: pharmaceutical primary standard
• Agency: EP Reference Standard
• familia API: isoniazid
• fabricante / nombre comercial: EDQM
• mp: 171-173 °C (lit.)
• aplicaciones: pharmaceutical (small molecule)
• formato: neat
• temp. de almacenamiento: 2-8°C
• cadena SMILES: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• Clave InChI: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Descripción

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Isoniazid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H315
• Consejos de prudencia: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Clasificaciones de peligro: Acute Tox. 4 Oral - Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3