SRP6170

IL-2 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

• Sinónimos: Aldesleukin, Lymphokine, N/A, T-cell growth factor (TCGF)
• Número de CAS: 110942-02-4
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• origen biológico: human
• recombinante: expressed in HEK 293 cells
• Análisis: ≥95% (SDS-PAGE)
• formulario: lyophilized
• potencia: 0.2-2 ng/mL
• mol peso: 15 kDa (monomer, glycosylated)
• envase: pkg of 10 μg
• técnicas: cell culture | mammalian: suitable
• Nº de acceso NCBI: P60568
• Nº de acceso UniProt: P60568
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: human ... IL2(3558)

Descripción

Descripción general

IL-2 (interleukin 2) is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is a type I cytokine. Recombinant human IL-2 is a 15.5kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

The IL-2 gene is mapped to human chromosome 4q27.

Aplicación

IL-2 (interleukin 2) human has been used for the stimulation of human primary naive T lymphocytes to study the effect of microRNA-146a on IL-2 activation-induced cell death.

Acciones bioquímicas o fisiológicas

IL-2/IL-2R (interleukin 2/IL-2 receptor) signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK (natural killer) cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. It is associated with recurrent oral ulcer and asthma and Mycoplasma pneumoniae infection in children. Absence of IL-2 in mice causes fatal lymphoproliferative inflammatory disease (IL-2 deficiency syndrome). IL-2 signaling involves three pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAPK (mitogen activated protein kinase), and JAK-STAT (Janus kinase - signal transducers and activators of transcription) pathways.

Forma física

Lyophilized from a PBS solution.

Nota de preparación

Centrifuge the vial prior to opening.

Reconstitución

Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable