I2644

IL-2 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Sinónimos: IL-2, Interleukin-2, Interleukin-2 human, T-cell growth factor, hIL-2
• Número MDL: MFCD00165721
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nombre del producto: Interleukin-2 human, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• origen biológico: human
• Nivel de calidad: 200
• recombinante: expressed in E. coli
• Formulario: lyophilized powder
• potencia: ≤700 EC₅₀
• calidad: endotoxin tested
• mol peso: 15.5 kDa
• envase: pkg of 5X10 μg; pkg of 10 μg
• técnicas: cell culture | mammalian: suitable
• impurezas: ≤1 EU/μg
• Nº de acceso UniProt: P60568
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... IL2(3558)

Descripción

Descripción general

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

Aplicación

Interleukin-2 human has been used:

• in the stimulation of natural killer cells
• to study its ability to stimulate lymphocyte growth and prevent apoptosis
• as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus

Acciones bioquímicas o fisiológicas

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. It mediates CD41⁺ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.

Forma física

Lyophilized, 0.2 μm filtered, no additives.

Nota de análisis

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)