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Key Documents

SRP6158

Sigma-Aldrich

EPO human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sinónimos:

EP, EPO-alpha, Epoetin, Erythropoietin-alpha, MGC138142

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About This Item

Número de CAS:
Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

human

recombinante

expressed in HEK 293 cells

Análisis

≥95% (SDS-PAGE)

formulario

lyophilized

mol peso

36 kDa (monomer, glycosylated)

envase

pkg of 10 μg

técnicas

cell culture | mammalian: suitable

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... EPO(2056)

Descripción general

The gene EPO (erythropoietin) is mapped to human chromosome 7q22. It is a glycoprotein hormone. EPO is generated in fetal liver and adult kidney. However, it can also be secreted by other organs, such as the heart, brain and lungs. EPO is a member of the EPO/TPO (thrombopoietin) family and is found in the plasma.

Aplicación

  • EPO (erythropoietin) has been used as a component of the culture medium for cardiac stem cells.
  • In cultured cerebellar granule cells and hippocampal neurons, it has been used to study effect of EPO on glutamate release.
  • It has also been used as a component of endothelial differentiation medium.

Acciones bioquímicas o fisiológicas

EPO (erythropoietin) regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It interacts with EPO receptor and is responsible for the cellular responses. EPO is expressed in many cancers, including breast cancer, renal cancer, gastric cancer, hepatocellular carcinoma and central nervous system tumors. In addition, it is a hypoxia responsive cytokine and a pro-angiogenic factor. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. It can protect from brain damages due to ischemia and enhances memory as well as cognitive ability in humans suffering from vascular dementia.

Forma física

Lyophilized from a PBS solution.

Nota de preparación

Centrifuge the vial prior to opening.

Reconstitución

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Beth J Allison et al.
Journal of applied physiology (Bethesda, Md. : 1985), 126(1), 44-50 (2018-11-02)
Erythropoietin (EPO) is being trialled in preterm infants to reduce brain injury, but high doses increase lung injury in ventilated preterm lambs. We aimed to determine whether early administration of lower doses of EPO could reduce ventilation-induced lung injury and
Tessa Wilkin et al.
Drug testing and analysis, 9(9), 1456-1471 (2017-03-30)
A horse's success on the racetrack is determined by genetics, training and nutrition, and their translation into physical traits such as speed, endurance and muscle strength. Advances in genetic technologies are slowly explaining the roles of specific genes in equine
Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics.
Fang B, et al.
Blood, 105, 2733-2740 (2005)
Zhihong Yang et al.
International journal of clinical and experimental pathology, 8(4), 4033-4043 (2015-06-23)
To evaluate erythropoietin (Epo) and erythropoietin receptor (EpoR) expression, its relationship with vasculogenic mimicry (VM) and its prognostic value in human hepatocellular carcinoma (HCC), we examined Epo/EpoR expression and VM formation using immunohistochemistry and CD31/PAS (periodic acid-Schiff) double staining on
Micro and nano-scale in vitro 3D culture system for cardiac stem cells.
Hosseinkhani H, et al.
Journal of Biomedical Materials Research Part A, 94, 1-8 (2010)

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