M6908
Myeloperoxidase from human leukocytes
lyophilized powder, ≥50 units/mg protein
Sinónimos:
MPO, Peroxidase, myelo
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About This Item
Número de CAS:
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.32
Productos recomendados
origen biológico
human leucocytes
Nivel de calidad
Formulario
lyophilized powder
actividad específica
≥50 units/mg protein
solubilidad
H2O: soluble
aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
cadena SMILES
[O+H2]O[O-]
InChI
1S/H2O3/c1-3-2/h1-2H
Clave InChI
JSPLKZUTYZBBKA-UHFFFAOYSA-N
Información sobre el gen
human ... MPO(4353)
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Descripción general
Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.
Aplicación
Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.
Myeloperoxidase from human leukocytes has been used:
- as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue
- as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages
- as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO
Acciones bioquímicas o fisiológicas
Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).
Otras notas
Lysosomal heme-containing protein.
Definición de unidad
One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C
Forma física
Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride
Nota de análisis
Source material tested and found negative for antibody to HIV and for HBSAG.
Inhibidor
Referencia del producto
Descripción
Precios
sustrato
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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