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SAB4501038

Sigma-Aldrich

Anti-MTOR antibody produced in rabbit

affinity isolated antibody

Sinónimos:

FRAP, FRAP1, FRAP2, RAFT1, Rapamycin target protein

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25 MG
₹5,786.00
100 MG
₹12,936.00
1 G
₹72,985.00

₹5,786.00


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25 MG
₹5,786.00
100 MG
₹12,936.00
1 G
₹72,985.00

About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

₹5,786.00


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origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

mol peso

antigen 2888 kDa

reactividad de especies

rat, human, mouse

concentración

~1 mg/mL

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1 of 4

Este artículo
ZRB2086ZRB1729ZRB2045
clone

3N22-1, recombinant monoclonal

clone

1D11, recombinant monoclonal

clone

3N20, recombinant monoclonal

clone

2H5, recombinant monoclonal

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

Gene Information

human ... SDC1(6382)

Gene Information

human ... DDR1(780)

Gene Information

human ... CREBBP(1387)

Gene Information

human ... UBE2I(7329)

species reactivity

mouse, human

species reactivity

human

species reactivity

human

species reactivity

monkey, human, mouse

Descripción general

Anti-MTOR antibody detects endogenous levels of total MTOR protein.
The mechanistic/mammalian target of rapamycin (mTOR) is a serine/threonine kinase. It is a member of the phosphatidylinositide 3-kinases (PI 3-kinases or PI3Ks) family. It is mapped to human chromosome 1p36.22.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human mTOR.

Immunogen Range: 2447-2496

Aplicación

Anti-MTOR, C-Terminal antibody has been used in western blotting.

Acciones bioquímicas o fisiológicas

The mechanistic/mammalian target of rapamycin (mTOR) controls protein translation, cell growth, survival, invasion and metabolism. It acts as an intracellular signalling regulator which links the extracellular events to the intracellular process. mTOR also acts on the protein synthesis machinery.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Visite la Librería de documentos

Lexing Li et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(4), 1723-1734 (2018-08-06)
Autophagy is a process of evolutionarily conservative degradation, which could maintain cellular homeostasis and cope with various types of stress. LncRNAs are considered as competing endogenous RNAs (ceRNAs) contributing to autophagy. GAS5 has been suggested as a new potential factor
Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition
Marques-Ramos A, et al.
RNA (2017)
The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma
Miyahara H, et al.
Cancer Letters, 400, 110-116 (2017)
Expression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course
Jia W, et al.
Anticancer Research, 33(8), 3123-3131 (2013)
Fengling Song et al.
Journal of cellular physiology, 234(5), 7420-7434 (2018-10-27)
Long noncoding RNA urothelial carcinoma associated 1 (UCA1) has been implicated in the growth and metastasis of colorectal cancer (CRC), and autophagy contributes to tumorigenesis and cancer cell survival. However, the regulatory role of UCA1 in CRC cell viability by

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