SAB4502262

Anti-PPAR-γ antibody produced in rabbit

affinity isolated antibody

• Sinónimos: NR1C3, PPAR-γ-1, Peroxisome proliferator activated receptor γ
• Número MDL: MFCD01092470
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 57 kDa
• reactividad de especies: mouse, rat, human
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Nº de acceso NCBI: P37231
• Nº de acceso UniProt: P37231
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PPARG(5468)

Descripción

Descripción general

Peroxisome proliferator-activated receptor γ (PPARγ) is one of the subtypes of PPAR, and belongs to the nuclear hormone receptor superfamily. PPARγ is further sub classified into four isoforms and they have tissue specific expression. PPARγ is encoded by the gene mapped to human chromosome 3p25. PPARγ contains N- terminal AF (activation function)-1 transactivation domain, followed by a DNA-binding domain and a dimerization and ligand-binding domain.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human PPAR-gamma.

Immunogen Range: 78-127

Acciones bioquímicas o fisiológicas

Peroxisome proliferator-activated receptor γ (PPARγ) induces the expression of genes coding for proteins implicated in glucose and lipid metabolism. Natural PPAR-γ agonists found in foods functions as an anti-inflammatory molecule, thus, PPARγ is not only a target of the pharmaceutical industry, but also a novel target of the food industry. PPAR-γ regulates energy storage, adipocyte differentiation, and cellular inflammatory and ischemic responses. PPARγ is also involved in the production of prostanoids that regulate vascular function. PPARγ agonists, thiazolidinediones including rosiglitazone and pioglitazone, enhance insulin sensitivity by inhibiting the tumor necrosis factor α (TNF-α) activity in adipocytes. These PPAR-γ agonists are used in the treatment of type 2 diabetes. PPARγ functions as a potential therapeutic target in pulmonary hypertension.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable