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S4068

Sigma-Aldrich

Splitomicin

≥98% (HPLC), powder

Sinónimos:

1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

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About This Item

Fórmula empírica (notación de Hill):
C13H10O2
Número de CAS:
5690-03-9
Peso molecular:
198.22
Número MDL:
MFCD08705254
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24724608
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

temp. de almacenamiento

2-8°C

cadena SMILES

O=C1CCc2c(O1)ccc3ccccc23

InChI

1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2

Clave InChI

ISFPDBUKMJDAJH-UHFFFAOYSA-N

Aplicación

Splitomicin was used to inhibit SIRT1 in human aortic endothelial cells and sirtuins in human breast cancer cells. Mouse leukaemic monocyte macrophage cell line was treated with Splitomicin prior to cholesterol efflux studies.

Acciones bioquímicas o fisiológicas

Splitomicin, a derivative of β-naphthol is an inhibitor of Silent Information Regulator 2 (SIR2). It inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release. This results in inhibition of platelet aggregation that is effective in cardiovascular and cerebrovascular diseases.
Sir2p (silent information regulator) and HDAC inhibitor.

Características y beneficios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Producto relacionado

Referencia del producto
Descripción
Precios

EPI004

Histone Deacetylase 3 (HDAC3) Activity Assay Kit, 100 assays in 96 well plates

EPI005

Histone Deacetylase 3 (HDAC3) Inhibitor Screening Kit, 100 assays in 96 well plates

EPI006

Histone Deacetylase 8 (HDAC8) Activity Assay Kit, 100 assays in 96 well plates

EPI007

Histone Deacetylase 8 (HDAC8) Inhibitor Screening Kit, 100 assays in 96 well plates

EPI008

Histone Deacetylase (HDAC) Inhibitor Set I, Set includes 6 inhibitors

EPI010

Sirtuin 2 (SIRT2) Inhibitor Screening Assay Kit, 100 assays in 96 well plates

EPI009

Histone Deacetylase (HDAC) Inhibitor Set II, Set includes 7 inhibitors

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Evi X Stavrou et al.
Blood, 125(4), 710-719 (2014-10-24)
The precise mechanism for reduced thrombosis in prekallikrein null mice (Klkb1(-/-)) is unknown. Klkb1(-/-) mice have delayed carotid artery occlusion times on the rose bengal and ferric chloride thrombosis models. Klkb1(-/-) plasmas have long-activated partial thromboplastin times and defective contact
Fu-Chao Liu et al.
Thrombosis research, 124(2), 199-207 (2009-03-31)
Splitomicin is derived from beta-naphthol and is an inhibitor of Silent Information Regulator 2 (SIR2). Its naphthoic moiety might be responsible for its inhibitory effects on platelets. The major goal of our study was to examine possible mechanisms of action
Gil Blander et al.
Annual review of biochemistry, 73, 417-435 (2004-06-11)
The yeast SIR protein complex has been implicated in transcription silencing and suppression of recombination. The Sir complex represses transcription at telomeres, mating-type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved in organisms ranging
Alexander Breitenstein et al.
Cardiovascular research, 89(2), 464-472 (2010-10-28)
The mammalian silent information regulator-two 1 (Sirt1) blunts the noxious effects of cardiovascular risk factors such as type 2 diabetes mellitus and obesity. Nevertheless, the role of Sirt1 in regulating the expression of tissue factor (TF), the key trigger of
Sokrates Stein et al.
Aging, 2(6), 353-360 (2010-07-08)
Excessive production of reactive oxygen species (ROS) contributes to progression of atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory activation. The class III histone deacetylase SIRT1 has been implicated in extension of lifespan. In the vasculature,SIRT1 gain-of-function
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