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A8231

Sigma-Aldrich

AGK2

≥97% (HPLC), powder

Sinónimos:

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

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About This Item

Fórmula empírica (notación de Hill):
C23H13Cl2N3O2
Número de CAS:
304896-28-4
Peso molecular:
434.27
Número MDL:
MFCD01909444
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329770953
NACRES:
NA.77

Ensayo

≥97% (HPLC)

Formulario

powder

solubilidad

DMSO: 2 mg/mL, clear (warmed)
H2O: insoluble

temp. de almacenamiento

room temp

cadena SMILES

Clc1ccc(Cl)c(c1)-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4ncccc34)o2

InChI

1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+

Clave InChI

SVENPFFEMUOOGK-SDNWHVSQSA-N

Aplicación

AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

Acciones bioquímicas o fisiológicas

AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.
AGK2 is a SIRT2 inhibitor; rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

Características y beneficios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
017M4705V
104M4742V
043M4738V
048K47024
048K47025

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Nicotinamide ≥99.5% (HPLC)

Sigma-Aldrich

72340

Nicotinamide

Trichostatin A ≥98% (HPLC), from Streptomyces sp.

Sigma-Aldrich

T8552

Trichostatin A

Lisa M Giammona et al.
Experimental hematology, 37(11), 1340-1352 (2009-09-01)
Megakaryocytic cells (Mks) undergo endomitosis and become polyploid. Mk ploidy correlates with platelet production. We previously showed that nicotinamide (NIC) greatly increases Mk ploidy in cultures of human mobilized peripheral blood CD34(+) cells. This study aims to examine the generality
David T She et al.
Molecular neurobiology, 55(12), 9188-9203 (2018-04-15)
Sirtuin 2 (SIRT2) is a family member of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases which appears to have detrimental roles in an array of neurological disorders such as Parkinson's disease (PD) and Huntington's disease (HD). In light of the recently emerging
G L Garrote et al.
The Journal of dairy research, 68(4), 639-652 (2002-04-04)
Chemical and microbiological composition of four Argentinean kefir grains from different sources as well as characteristics of the corresponding fermented milk were studied. Kefir grains CIDCA AGK1, AGK2 and AGK4 did not show significant differences in their chemical and microbiological
T Zhao et al.
Current molecular medicine, 15(7), 634-641 (2015-08-25)
Seven isoforms of histone deacetylase Class III have been reported - Sirtuin (SIRT) 1-7. We recently demonstrated that EX-527, an inhibitor of SIRT1, reduces mortality in a mouse model of lethal-cecal-ligationand- puncture (CLP)-induced septic shock. Our present study was aimed
Hai-Bo Yu et al.
International journal of medical sciences, 15(12), 1356-1364 (2018-10-03)
Sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD +)-dependent class III histone deacetylase. We have reported that HBx (hepatitis B virus X protein)-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis. However, the potential anti-HBV effect of AGK2, a selective inhibitor
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