72340

Nicotinamide

≥99.5% (HPLC)

• Sinónimos: Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B₃, Vitamin PP
• Fórmula empírica (notación de Hill): C₆H₆N₂O
• Número de CAS: 98-92-0
• Peso molecular: 122.12
• Beilstein: 383619
• Número CE: 202-713-4
• Número MDL: MFCD00006395
• Código UNSPSC: 12352205
• ID de la sustancia en PubChem: 57652413
• NACRES: NA.79

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 200
• Ensayo: ≥99.5% (HPLC)
• Formulario: powder or crystals
• residuo de ign.: ≤0.2%
• pérdida: ≤0.2% loss on drying, 20 °C (HV)
• color: colorless to white
• mp: 128-131 °C (lit.); 128-131 °C
• trazas de anión: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤150 mg/kg
• trazas de catión: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• aplicaciones: cell analysis
• cadena SMILES: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
• Clave InChI: DFPAKSUCGFBDDF-UHFFFAOYSA-N
• Información sobre el gen: human ... PARP1(142) , SIRT2(22933)

Descripción

Descripción general

Nicotinamide, a form of vitamin B3, is a building block of coenzymes NAD and NADP. Researchers consider it an important signaling molecule, and essential for cell metabolism studies. It has been used in multiple applications and research areas, namely cancer and viral research.

Aplicación

Nicotinamide has been used:

• to study its effect on the expression of sirtuin 1
• in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay
• in cell lysis buffer, to serve as a sirtuin 1 inhibitor in order to study its role in resveratrol (RSV)-stimulated hepatitis B virus replication

Acciones bioquímicas o fisiológicas

Nicotinamide (Niacinamide) (Nam) is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). Nicotinamide may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule.

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

The coenzymes NAD and NADP take part in energy yielding metabolism and mediate several oxidation-reduction reactions. NAD hydrolyses to form nicotinamide, which is then transported to other tissues. Hydrolysis of nicotinamide yields nicotinic acid through salvage pathway.

Otras notas

Coenzymes and Cofactors, vol. 2: Pyridine Nucleotide Coenzymes

Información de seguridad

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