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N6803

Sigma-Aldrich

Nystatin water soluble

suitable for cell culture

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About This Item

Código UNSPSC:
12352207

origen biológico

synthetic

formulario

powder

mol peso

1029.23 g/mol

técnicas

cell culture | mammalian: suitable

solubilidad

100 mg/mL

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Categorías relacionadas

Descripción general

Nystatin is a polyene, broad-spectrum antibiotic. It can modify the microstructure of lipid rafts and sequestrate cholesterol present on the cell membrane of eukaryotes. Thus, nystatin can modulate immune responses. This is carried out through cytokine signaling, activation of lymphocytes and pathogen recognition.
Molecular Formula: C51H84N2O19
Molecular Weight: 1029.23
Nystatin water soluble is a Nystatin derivate with fungistatic and fungicidal activity in resemblance to Nystatin. However, as opposed to the poor solubility of Nystatin the water soluble derivate can be dissolved in concentration of up to 100mg/ml. Nystatin binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active against Candida species. However, it is also reported to be effective against Aspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin to Saccharomyces cerevisiae was reported to be 3μg/ml while for clinical isolates of Candida albicans the MIC was reported to be 4-16μg/ml.

Otras notas

Technical data

  • Nystatin water soluble is a fully solubilized powder of Nystatin with potency of ≥2000 units/mg according to USP standard.
  • Nystatin water soluble is 0.2μm filtered and endotoxin free.
  • The suggest working concentration of Nystatin water soluble is 100 units/ml.
  • It is recommended to store solutions of Nystatin water soluble in the dark.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

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Water-Soluble Nystatin and Derivative
Aviran Amir, Michal Levin-Khalifa, and Tamar Dvash
ACS Medicinal Chemistry Letters, 182?187-182?187 (2022)
Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal candidiasis
Zhang X, et al.
BMC Microbiology, 18(1), 166-166 (2018)

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