L2023

Leupeptin trifluoroacetate salt

powder, ≥90% (HPLC)

• Sinónimos: Acetyl-Leu-Leu-Arg-al trifluoroacetate salt
• Fórmula empírica (notación de Hill): C₂₀H₃₈N₆O₄ · xC₂HF₃O₂
• Número de CAS: 147385-61-3
• Peso molecular: 426.55 (free base basis)
• Número MDL: MFCD00133458
• Código UNSPSC: 12352202
• ID de la sustancia en PubChem: 329817397
• NACRES: NA.77

Propiedades

• product name: Leupeptin trifluoroacetate salt, ≥90% (HPLC), microbial
• origen biológico: microbial
• Nivel de calidad: 200
• Análisis: ≥90% (HPLC)
• formulario: powder
• solubilidad: H₂O: 10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20 °C.)
• temp. de almacenamiento: −20°C
• cadena SMILES: OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O
• InChI: 1S/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1
• Clave InChI: WUHGBZVQELGOMH-FRKSIBALSA-N

Descripción

Acciones bioquímicas o fisiológicas

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Nota de análisis

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)