C4650
Cholestyramine resin
Sinónimos:
Colestyramine, Dowex 1X2 Cl--Form
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About This Item
Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
23151817
NACRES:
NA.56
Productos recomendados
formulario
powder
Nivel de calidad
técnicas
activity assay: suitable
matriz
polystyrene/divinylbenzene
pH
4—6
capacidad
~1.0 meq/g(dry)
Aplicación
Cholestyramine resin has been used:
- as a diet supplement to study the bile acid pool size and fecal bile acid output in mice
- to alter the bile acid (BA) levels and study its effect on liver fibrosis development in wild type (WT), fibroblast growth factor 15 (Fgf15)−/−, and Fgf15 transgenic (TG) mice
- in in vitro digestion process to study the capacity of the fractions for binding bile acid (BA)
Cholestyramine resin is used in protein chromatography, ion exchange chromatography and anion exchange media. Cholestyramine has been used to study the relief of postcholecystectomy diarrhea, the management of intractable cholestatic pruritus and obesity.
Acciones bioquímicas o fisiológicas
Cholestyramine is a cationic exchange resin polymer. This resin is a bile acid sequestrant that interchanges chloride anions for bile acids of the small intestine lumen, leading to excretion of bile acids in the feces and reduced levels of serum bile acid. Cholestyramine is used to treat primary hypercholesterolemia. The resin induces dose-dependent reduction of low-density lipid (LDL) cholesterol. It ameliorates the risk of coronary artery disease.
Otras notas
Quartenary ammonium functional groups attached to cross-linked polystyrene
Información legal
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
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