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C1129

Sigma-Aldrich

Cholic acid

from bovine and/or ovine, ≥98%

Sinónimos:

3α,7α,12α-Trihydroxy-5β-cholanic acid, Cholanic acid

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About This Item

Fórmula empírica (notación de Hill):
C24H40O5
Número de CAS:
81-25-4
Peso molecular:
408.57
Beilstein:
2822009
Número CE:
201-337-8
Número MDL:
MFCD00003672
Código UNSPSC:
12161900
ID de la sustancia en PubChem:
24892356
NACRES:
NA.25

origen biológico

bovine and/or ovine

Nivel de calidad

200

descripción

anionic

Análisis

≥98%

formulario

powder

mol peso

408.57 g/mol

mp

200-201 °C (lit.)

grupo funcional

carboxylic acid

Condiciones de envío

ambient

temp. de almacenamiento

room temp

cadena SMILES

[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@]([H])(CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(O)=O

InChI

1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1

Clave InChI

BHQCQFFYRZLCQQ-OELDTZBJSA-N

Información sobre el gen

human ... CYP1A2(1544)

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Descripción general

Cholic acid is a major primary bile acid produced in the liver which facilitates fat absorption and cholesterol excretion. It is a non-denaturing ionic detergent.

Aplicación

Dietary cholic acid has been used in a study to assess its effect on colonic epithelial cell proliferation. It has also been used in a study to investigate extractions and comparisons of human erythrocyte ghosts.
Non-denaturing ionic detergent used for extraction of membrane proteins.

Acciones bioquímicas o fisiológicas

Bile Acid

Producto relacionado

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Cholic acid-2,2,4,4-d4 98 atom % D, 98% (CP)

Sigma-Aldrich

614149

Cholic acid-2,2,4,4-d4

Deoxycholic acid ≥99.0% (T)

Sigma-Aldrich

30960

Deoxycholic acid

Chenodeoxycholic acid European Pharmacopoeia (EP) Reference Standard

C1050000

Chenodeoxycholic acid

Bile acids, conjugated

Sigma-Aldrich

CBA

Bile acids, conjugated

R Coleman et al.
Biochimica et biophysica acta, 436(1), 38-44 (1976-06-04)
1. Human erythrocyte ghosts were extracted with individual free and conjugated bile salts and, for comparison, with Triton X-100 under conditions approximating to physiological temperature, pH and tonicity. 2. Treatment with cholate, glycocholate, taurocholate, or with Triton X-100 gave lipid-depleted
Hui Zhou et al.
JCI insight, 5(20) (2020-10-16)
High-fat feeding (HFF) leads to gut dysbiosis through unclear mechanisms. We hypothesize that bile acids secreted in response to high-fat diets (HFDs) may act on intestinal Paneth cells, leading to gut dysbiosis. We found that HFF resulted in widespread taxonomic
E E Deschner et al.
Digestion, 21(6), 290-296 (1981-01-01)
Administration of cholic acid (1.0% of the diet) to male Fisher rats for 3 days resulted in increased numbers of DNA synthesizing epithelial cells per colonic crypt column as compared to those found in either control or 0.2% cholic acid-fed
Michael Lazarou et al.
The FEBS journal, 276(22), 6701-6713 (2009-10-22)
Complex IV is the terminal enzyme of the mitochondrial respiratory chain. In humans, biogenesis of complex IV involves the coordinated assembly of 13 subunits encoded by both mitochondrial and nuclear genomes. The early stages of complex IV assembly involving mitochondrial
Roberto Pellicciari et al.
Journal of medicinal chemistry, 52(24), 7958-7961 (2009-12-18)
In the framework of the design and development of TGR5 agonists, we reported that the introduction of a C(23)(S)-methyl group in the side chain of bile acids such as chenodeoxycholic acid (CDCA) and 6-ethylchenodeoxycholic acid (6-ECDCA, INT-747) affords selectivity for
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