B9935
BMS-345541
≥98% (HPLC), powder
Sinónimos:
N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride
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About This Item
Fórmula empírica (notación de Hill):
C14H17N5 · HCl
Número de CAS:
Peso molecular:
291.78
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
Nivel de calidad
Análisis
≥98% (HPLC)
formulario
powder
condiciones de almacenamiento
desiccated
solubilidad
DMSO: 18 mg/mL
H2O: insoluble
emisor
Bristol-Myers Squibb
temp. de almacenamiento
2-8°C
cadena SMILES
Cl[H].Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1
InChI
1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H
Clave InChI
MIDKPVLYXNLFGZ-UHFFFAOYSA-N
Aplicación
BMS-345541 has been used:
- as an IκB kinase (IKK) complex inhibitor to study its effects on the interferon-γ (IFN-γ) production by natural killer (NK) cells
- as an IKK inhibitor to study its effects on the expression of eotaxin and monocyte chemoattractant protein-1 (MCP-1) mRNA in gingival fibroblasts
- as nuclear factor κB (NF-κB) pathway inhibitor to study its effects on tumor necrosis factor α (TNFα) production in human oral squamous carcinoma cells
Acciones bioquímicas o fisiológicas
BMS-345541 possesses anti-inflammatory properties. It also blocks the nuclear factor κB (NF-κB)-dependent transcription of pro-inflammatory cytokines. BMS-345541 possesses anti-inflammatory activity and plays a role in arresting bone erosion in certain animal models.
BMS-345541 is an IKB kinase (IKK) allosteric site inhibitor.
Características y beneficios
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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