L9908

LY-294,002 hydrochloride

from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor

• Sinónimos: 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
• Fórmula empírica (notación de Hill): C₁₉H₁₇NO₃ · HCl
• Número de CAS: 934389-88-5
• Peso molecular: 343.80
• Número MDL: MFCD00270881
• Código UNSPSC: 12352207
• ID de la sustancia en PubChem: 24278828
• NACRES: NA.77

Propiedades

• Nombre del producto: LY-294,002 hydrochloride, solid, ≥98% (HPLC)
• origen biológico: microbial (Staphylococcus roseus)
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• color: white to off-white
• solubilidad: DMSO: >5 mg/mL; H₂O: insoluble
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
• InChI: 1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
• Clave InChI: CZQHHVNHHHRRDU-UHFFFAOYSA-N

Descripción

Descripción general

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Aplicación

LY-294,002 hydrochloride has been used in the inhibition of:

• phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
• autophagy in mesenchymal stem cells (MSCs).
• serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.

Acciones bioquímicas o fisiológicas

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

Características y beneficios

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)