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Merck

B9685

Sigma-Aldrich

BAY 61-3606 hydrochloride hydrate

≥98% (HPLC), powder

Sinónimos:

2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C20H18N6O3 · xHCl · yH2O
Peso molecular:
390.40 (anhydrous free base basis)
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

Análisis

≥98% (HPLC)

formulario

powder

potencia

7.5 nM Ki

condiciones de almacenamiento

desiccated

color

yellow

solubilidad

H2O: soluble

emisor

Bayer

temp. de almacenamiento

2-8°C

cadena SMILES

O.Cl.COc1ccc(cc1OC)-c2cc3nccn3c(Nc4ncccc4C(N)=O)n2

InChI

1S/C20H18N6O3.ClH.H2O/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H;1H2

Clave InChI

WYXPKEXHEJAVSI-UHFFFAOYSA-N

Aplicación

BAY 61-3606 hydrochloride hydrate has been used in focal cerebral ischemia model. It has also been used to assess the effect of Syk in stroke-induced injury.

Acciones bioquímicas o fisiológicas

BAY 61-3606 helps to prevent the degranulation of freshly isolated basophils. It also prevents B cell receptor (BCR)-mediated signaling.
Spleen tyrosine kinase (Syk) inhibitor; anti-inflammatory. Syk plays a major role in inflammation pathways via receptors for the Fc portion of immunoglobulins, as well as B cell signaling. It is orally active, potent (Ki 7.5 nM), and highly selective for Syk vs other kinases (Lyn, Fyn, Src, Itk, Btk; Ki′s).

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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An atypical role for the myeloid receptor Mincle in CNS injury
Arumugam T, et al.
bioRxiv, 044602-044602 (2016)
An atypical role for the myeloid receptor Mincle in central nervous system injury
Arumugam T V, et al.
Journal of Cerebral Blood Flow and Metabolism, 37(6), 2098-2111 (2017)
The orally available spleen tyrosine kinase inhibitor 2-[7-(3, 4-dimethoxyphenyl)-imidazo [1, 2-c] pyrimidin-5-ylamino] nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents
Yamamoto N, et al.
Journal of Pharmacology and Experimental Therapeutics, 306(3), 1174-1181 (2003)
Tomer Illouz et al.
Communications biology, 4(1), 329-329 (2021-03-14)
Maternal antibodies (MAbs) protect against infections in immunologically-immature neonates. Maternally transferred immunity may also be harnessed to target diseases associated with endogenous protein misfolding and aggregation, such as Alzheimer's disease (AD) and AD-pathology in Down syndrome (DS). While familial early-onset

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