Q3251

Quinacrine dihydrochloride

≥90% (TLC), powder, MAO-A/B inhibitor

• Sinónimos: 6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride
• Fórmula empírica (notación de Hill): C₂₃H₃₀ClN₃O · 2HCl
• Número de CAS: 69-05-6
• Peso molecular: 472.88
• Beilstein: 4834013
• Número CE: 200-700-8
• Número MDL: MFCD00012659
• Código UNSPSC: 12352101
• ID de la sustancia en PubChem: 24278192
• NACRES: NA.77

Propiedades

• product name: Quinacrine dihydrochloride, ≥90%
• origen biológico: synthetic
• Nivel de calidad: 100
• Análisis: ≥90%
• formulario: powder
• mp: 257 °C
• solubilidad: H₂O: soluble, clear to hazy
• emisor: Bayer
• cadena SMILES: Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
• InChI: 1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
• Clave InChI: UDKVBVICMUEIKS-UHFFFAOYSA-N
• Información sobre el gen: human ... MAOA(4128) , MAOB(4129)

Descripción

Descripción general

Quinacrine is an acridine derivative and a potent antimalarial agent.

Aplicación

Quinacrine dihydrochloride has been used:

• in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
• in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
• in uptake-release assay for characterization of dense granule functionality of platelets

Acciones bioquímicas o fisiológicas

Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases. Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections. It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.

Non-selective MAO-A/B inhibitor.

Características y beneficios

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Almacenamiento y estabilidad

Stock solutions are stable for up to 60 h at 20°C.

Otras notas

This product is not assigned an expiration date or recommended retest date.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves