574713

Syk Inhibitor III

The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: Syk Inhibitor III, 3,4-Methylenedioxy-β-nitrostyrene
• Fórmula empírica (notación de Hill): C₉H₇NO₄
• Número de CAS: 1485-00-3
• Peso molecular: 193.16
• Número MDL: MFCD00014575
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (GC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow to brown
• solubilidad: DMSO: 25 mg/mL (Use only fresh DMSO.)
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-
• Clave InChI: KFLWBZPSJQPRDD-ARJAWSKDSA-N

Descripción

Descripción general

A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC₅₀ = 2.5 µM). It inhibits Src only at much higher concentrations (IC₅₀ = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC₅₀ ranges from 2.1 to 25.9 µM).

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Syk

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2.5 µM against Syk kinase activity

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Wang, W.Y., et al. 2006. Mol. Pharmacol.70, 1380.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319
• Consejos de prudencia: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3