527455

PKR Inhibitor, Negative Control

The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: PKR Inhibitor, Negative Control, RNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
• Fórmula empírica (notación de Hill): C₁₅H₈Cl₃NO₂
• Número de CAS: 852547-30-9
• Peso molecular: 340.59
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (sum of two isomers, HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow
• solubilidad: DMSO: 10 mg/mL; ethanol: 10 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C15H8Cl3NO2/c16-8-1-2-13-9(6-8)10(15(21)19-13)3-7-4-11(17)14(20)12(18)5-7/h1-6,20H,(H,19,21)
• Clave InChI: ZJFMARHFPUZEKI-UHFFFAOYSA-N

Descripción

Descripción general

An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC₅₀ >100 µM) or in rescuing PKR-dependent translation block.

An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in the inhibition of RNA-induced PKR autophosphorylation (IC₅₀ >100 µM). Exhibits no ability to rescue the translational block imposed by human PKR.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
A negative control for PKR Inhibitor

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1