681665

Wnt Agonist

The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinónimos: Wnt Agonist, 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
• Fórmula empírica (notación de Hill): C₁₉H₁₈N₄O₃
• Número de CAS: 853220-52-7
• Peso molecular: 350.37
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: solid (sticky)
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellowish
• solubilidad: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
• Clave InChI: FABQUVYDAXWUQP-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC₅₀ >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC₅₀ = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664).

A cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC₅₀ >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC₅₀ = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

EC50 = 700 nM inducing β-catenin and TCF (T-cell fate)-dependent transcriptional activity in HEK-293T cells

Primary Target
Selective activator of Wnt signaling

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Liu, J., et al. 2005. Angew. Chem. Int. Ed.44, 1987.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable