235135

Corticosterone

≥95% (HPLC), crystalline powder, corticosteroid hormone, Calbiochem

• Sinónimos: Corticosterone, (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H
• Fórmula empírica (notación de Hill): C₂₁H₃₀O₄
• Número de CAS: 50-22-6
• Peso molecular: 346.46
• Número MDL: MFCD00037715
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: Corticosterone, Corticosteroid hormone synthesized in response to stress.
• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: crystalline powder
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: off-white; white to tan
• solubilidad: ethanol: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• Clave InChI: OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Descripción

Descripción general

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered expression which eventually affects ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Mineralocorticoid and glucocorticoid receptors

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3