C-113

Cortisol-D₄ (9,11,12, 12-D₄) solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Sinónimos: Cortisol-D4 (9,11,12,12-D4) solution, Hydrocortisone-9,11,12,12-D4 solution
• Fórmula empírica (notación de Hill): C₂₁H₂₆D₄O₅
• Número de CAS: 73565-87-4
• Peso molecular: 366.48
• Número CE: 200-659-6
• Número MDL: MFCD10567120
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329774859
• NACRES: NA.24

Propiedades

• grado: certified reference material
• Nivel de calidad: 300
• formulario: liquid
• Características: Snap-N-Spike^®/Snap-N-Shoot^®
• envase: ampule of 1 mL
• fabricante / nombre comercial: Cerilliant^®
• concentración: 100 μg/mL in methanol
• técnicas: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicaciones: clinical testing; clinical testing
• formato: single component solution
• temp. de almacenamiento: −20°C
• cadena SMILES: [2H]C1([2H])[C@]([2H])(O)[C@@]2([2H])[C@@H](CCC3=CC(=O)CC[C@]23C)[C@@H]4CCC(O)(C(=O)CO)[C@@]14C
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1/i10D2,16D,18D
• Clave InChI: JYGXADMDTFJGBT-BJJKTIQHSA-N

Descripción

Descripción general

Cortisol-D₄ (9,11,12, 12-D4) is the deuterated form of the glucocorticoid, cortisol. This stable labeled internal standard is suitable for quantitation of cortisol levels in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing’s syndrome, Addison’s disease, and Sheehan’s syndrome.

Aplicación

This Certified Spiking Solution^® is suitable for GC/MS and LC/MS applications from clinical and diagnostic testing and endocrinology to sports testing.The Certified Reference Material (CRM) in solution can also be used as an internal standard as follows:

• Identification of cortisol by atmospheric pressure chemical ionization (APCI) and selected reaction monitoring (SRM) during the high-performance liquid chromatography- tandem mass spectrometric (HPLC-MS/MS) analysis of cortisol in human sweat samples
• Combined determination of cortisol and cortisone in 48 serum samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS)
• Development and validation of an LC-MS/MS method to determine five steroids― free cortisol, cortisone, tetrahydrocortisol, allo-tetrahydrocortisol, and tetrahydrocortisone in urine samples
• Multi-residue analysis of cortisol, cortisone, and dehydroepiandrosterone sulfate (DHEAS) in 103 hair samples by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-MS/MS)
• Rapid LC-MS/MS-based assay of cortisol in 2860 serum samples over a duration of one year, using a simple protein precipitation technique for sample preparation

Características y beneficios

• Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
• Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
• Rigorously tested through real-time stability studies to ensure accuracy and shelf life
• Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
• Flame sealed under argon into ampoules for long-term shelf life
• Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H225,H301 + H311 + H331,H370
• Consejos de prudencia: P210 - P260 - P280 - P301 + P310 - P311
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 49.5 °F - closed cup
• Punto de inflamabilidad (°C): 9.7 °C - closed cup