C2505

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

• Sinónimos: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• Fórmula empírica (notación de Hill): C₂₁H₃₀O₄
• Número de CAS: 50-22-6
• Peso molecular: 346.46
• Beilstein: 2339601
• Número CE: 200-019-6
• Número MDL: MFCD00037715
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 24278302
• NACRES: NA.77

Propiedades

• Nombre del producto: Corticosterone, ≥92%
• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Ensayo: ≥92%
• Formulario: powder
• mp: 179-183 °C (lit.)
• solubilidad: chloroform: 50 mg/mL, clear, colorless to faintly yellow
• Condiciones de envío: ambient
• temp. de almacenamiento: room temp
• cadena SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• Clave InChI: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Información sobre el gen: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Descripción

Aplicación

Corticosterone has been used:

• in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
• as a stress inducing hormone in pregnant mice
• to test its effect on depression-related behaviors in mice

Acciones bioquímicas o fisiológicas

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves