219557

Cerulenin

from Cephalosporium caerulens, ≥98% (TLC), solid, de novo phospholipid synthesis inhibito, Calbiochem

• Sinónimos: Cerulenin, Cephalosporium caerulens
• Fórmula empírica (notación de Hill): C₁₂H₁₇NO₃
• Número de CAS: 17397-89-6
• Peso molecular: 223.27
• Número MDL: MFCD00083595
• Código UNSPSC: 41106500
• NACRES: NA.77

Propiedades

• product name: Cerulenin, Cephalosporium caerulens, An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis.
• Nivel de calidad: 100
• Análisis: ≥98% (TLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white to off-white
• solubilidad: DMSO: 10 mg/mL; ethanol: 5 mg/mL; acetone: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1
• Clave InChI: GVEZIHKRYBHEFX-NQQPLRFYSA-N

Descripción

Descripción general

An anti-fungal antibiotic that inhibits fatty acid biosynthesis by binding, in equimolar ratio, to β-keto-acyl-ACP synthase. Also inhibits sterol synthesis by blocking the activity of HMG-CoA synthetase activity. Systemic and intracerebroventricular of this compound reduces feeding and induces weight loss.

An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.

Acciones bioquímicas o fisiológicas

Primary Target
sterol & fatty acid biosynthesis

Envase

Packaged under inert gas

Advertencia

Toxicity: Harmful (C)

Otras notas

Loftus, T.M., et al. 2000. Science288, 2379.
Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable