860516P

C16 Ceramide (d18:1/16:0)

Avanti Research^™ - A Croda Brand

• Sinónimos: N-palmitoyl-D-erythro-sphingosine
• Fórmula empírica (notación de Hill): C₃₄H₆₇NO₃
• Número de CAS: 24696-26-2
• Peso molecular: 537.90
• Número MDL: MFCD00871748
• Código UNSPSC: 12352211
• NACRES: NA.25

Propiedades

• Formulario: powder
• envase: pkg of 1 × 10 mg (860516P-10mg); pkg of 1 × 100 mg (860516P-100mg); pkg of 1 × 25 mg (860516P-25mg); pkg of 1 × 5 mg (860516P-5mg); pkg of 1 × 50 mg (860516P-50mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand
• tipo de lípido: sphingolipids
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C34H67NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,32-33,36-37H,3-26,28,30-31H2,1-2H3,(H,35,38)/b29-27+/t32-,33+/m0/s1
• Clave InChI: YDNKGFDKKRUKPY-TURZORIXSA-N

Descripción

Descripción general

Ceramide comprise sphingosine and fatty acid and belongs to the sphingolipids family.

Aplicación

C16 Ceramide (d18:1/16:0) has been used:

• as an internal standard in the chromatography with negative ion electrospray ionization coupled to tandem mass spectrometry for myocardial ceramide quantification
• as an internal standard for the ceramide quantification from rat samples using liquid chromatography-mass spectrometry
• to test its effect on mitochondrial stress response in worms

Acciones bioquímicas o fisiológicas

C16 Ceramide levels are elevated in chronic alcohol-related liver disease (ALD). In general, ceramide inhibits mitochondrial function and insulin signaling. They are essential component of cell membrane and are involved in lipid raft formation. C16 ceramide based analog (C2-C16 CCPS) is potential anticancer agent used in chemotherapy. The levels of C16 ceramide and its ratio with other ceramides is regarded as a biomarker in predicting coronary artery disease (CAD). It interacts with the DNA-binding domain of tumor suppressor protein p53 and activates p53.

Envase

5 mL Amber Glass Screw Cap Vial (860516P-100mg)

5 mL Amber Glass Screw Cap Vial (860516P-10mg)

5 mL Amber Glass Screw Cap Vial (860516P-25mg)

5 mL Amber Glass Screw Cap Vial (860516P-50mg)

5 mL Amber Glass Screw Cap Vial (860516P-5mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable