850725P

18:1 (Δ9-Cis) PE (DOPE)

Avanti Research^™ - A Croda Brand

• Sinónimos: 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; DOPE; PE(18:1(9Z)/18:1(9Z)); 110635, DOPE
• Fórmula empírica (notación de Hill): C₄₁H₇₈NO₈P
• Número de CAS: 4004-05-1
• Peso molecular: 744.03
• Código UNSPSC: 51191904
• NACRES: NA.25

Propiedades

• descripción: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
• Análisis: >99% (TLC)
• formulario: powder
• envase: pkg of 1 × 1 g (850725P-1g); pkg of 2 × 100 mg (850725P-200mg); pkg of 5 × 100 mg (850725P-500mg); pkg of 1 × 25 mg (850725P-25mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand
• aplicaciones: advanced drug delivery
• tipo de lípido: cardiolipins; phospholipids
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: [H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
• InChI: 1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
• Clave InChI: MWRBNPKJOOWZPW-NYVOMTAGSA-N

Descripción

Descripción general

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) is a neutral phospholipid and displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH.

Aplicación

18:1 (Δ9-Cis) PE (DOPE) has been used in the preparation of liposome for human uncoupling protein 1 (UCP1) reconstitution and for Caenorhabditis elegans autophagy related cysteine protease protein conjugation studies. It has also been used for the generation of giant unilamellar vesicles (GUVs) for septin induced deformation studies.

Acciones bioquímicas o fisiológicas

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) forms a stable lipid layer and rapidly fuses with endosomal lipid bilayer. DOPE in combination with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) has high in vitro transfection efficiency.

Envase

20 mL Clear Glass Screw Cap Vial (850725P-1g)

5 mL Clear Glass Sealed Ampule (850725P-200mg)

5 mL Clear Glass Sealed Ampule (850725P-25mg)

5 mL Clear Glass Sealed Ampule (850725P-500mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable