901566

Propargyl-PEG₂-acid

• Fórmula empírica (notación de Hill): C₈H₁₂O₄
• Número de CAS: 1859379-85-3
• Peso molecular: 172.18
• Código UNSPSC: 12352106
• NACRES: NA.22

Propiedades

• formulario: liquid
• idoneidad de la reacción: reaction type: click chemistry; reagent type: linker
• grupo funcional: alkyne; carboxylic acid
• temp. de almacenamiento: −20°C
• cadena SMILES: C#CCOCCOCCC(O)=O

Descripción

Aplicación

Propargyl-PEG₂-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₂-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains two PEG units to help improve solubility.

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3