49920

Glycerol formal

≥98.0% (GC)

• Sinónimos: 1,3(or 2,3)-O-Methylene-1,2,3-propanetriol
• Fórmula empírica (notación de Hill): C₄H₈O₃
• Número de CAS: 99569-11-6
• Peso molecular: 104.10
• Beilstein: 103206
• Número MDL: MFCD10039829
• Código UNSPSC: 12352100
• ID de la sustancia en PubChem: 57651229
• NACRES: NA.22

Propiedades

• Nivel de calidad: 200
• Análisis: ≥98.0% (GC)
• contiene: ~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer
• composición: 5-hydroxy-1,3-dioxane, ~60% ; 4-hydroxymethyl-1,3-dioxolane, ~40%
• índice de refracción: n20/D 1.451 (lit.); n20/D 1.451
• bp: 192-193 °C (lit.)
• densidad: 1.203 g/mL at 25 °C (lit.)
• grupo funcional: ether; hydroxyl
• cadena SMILES: OCC1COCO1.OC2COCOC2
• InChI: 1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2
• Clave InChI: JIUMSISXCKWZTA-UHFFFAOYSA-N

Descripción

Descripción general

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.

Aplicación

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.

Información de seguridad

• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Eyeshields, Gloves, type ABEK (EN14387) respirator filter