202398

Poli(etilenglicol)

average M_n 400, hydroxyl

• Sinónimos: PEG
• Fórmula lineal: H(OCH₂CH₂)_nOH
• Número de CAS: 25322-68-3
• Número MDL: MFCD00081839
• Código UNSPSC: 12352104
• ID de la sustancia en PubChem: 24852060
• NACRES: NA.23

Propiedades

• Nombre del producto: Poli(etilenglicol), average M_n 400
• Formulario: viscous liquid
• mol peso: M_n 380-420; average M_n 400
• características de los productos alternativos más sostenibles: Safer Solvents and Auxiliaries; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• índice de refracción: n20/D 1.466
• pH: 4.5-7.5
• viscosidad: 7.3 cSt(210 °F)(lit.)
• mp: 4-8 °C (lit.)
• densidad: 1.128 g/mL
• Ω-final: hydroxyl
• α-final: hydroxyl
• categoría alternativa más sostenible: Aligned,
• cadena SMILES: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• Clave InChI: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Descripción

Descripción general

Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. PEGs are non-toxic, FDA-approved, generally non-immunogenic, and frequently used in many biomedical applications including bioconjugation, drug delivery, surface functionalization, and tissue engineering. In drug delivery, PEGs can be used as linkers for antibody-drug conjugates (ADCs) or as a surface coating on nanoparticles to improve systemic drug delivery.

Aplicación

Poly(ethylene glycol) (PEG) has been used as a coating agent for the synthesis and in vitro safety assessment of magnetic bacterial cellulose (MBC) pellicles, performed on porcine aortic smooth muscle cells (PAOSMC). PEG provides a compatible surface for cell culture, since uncoated iron oxide NPs are considered cytotoxic to cells. It has also been used as a plasticizer in investigating the effectiveness of polyvinylpyrrolidone microneedles for transdermal delivery of functional collagen using porcine skin, adult human skin analog and human foreskin. Microneedles obtained, were reportedly characterized by various analytical and bio-analytical techniques.

Solvent for greener fluorination of acetoacetamides with Selectfluor^®.

Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400

Used in conjunction with carbon black to form a conductive composite. Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.

Información legal

Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves