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SML0006
CK-666
≥98% (HPLC), powder, Arp2/3 comple inhibitor
Synonym(e):
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide, CK 666, CK-0944666
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About This Item
Empirische Formel (Hill-System):
C18H17FN2O
CAS-Nummer:
Molekulargewicht:
296.34
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
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Produktbezeichnung
CK-666, ≥98% (HPLC), powder
Qualitätsniveau
Assay
≥98% (HPLC)
Form
powder
Farbe
white to tan
Löslichkeit
DMSO: ≥25 mg/mL
Lagertemp.
2-8°C
SMILES String
Cc1[nH]c2ccccc2c1CCNC(=O)c3ccccc3F
InChI
1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
InChIKey
UXRKUKRXVWJFER-UHFFFAOYSA-N
Anwendung
CK-666 may be used to study Arp2/3-mediated structural changes in cells.
Biochem./physiol. Wirkung
CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation.
CK-666 is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Byron Hetrick et al.
Chemistry & biology, 20(5), 701-712 (2013-04-30)
Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to Arp2/3 complex and inhibit nucleation, but their modes of action are unknown. Here, we use biochemical and structural
Aaron S Dhanda et al.
mBio, 9(2) (2018-04-11)
Palladin is an important component of motile actin-rich structures and nucleates branched actin filament arrays in vitro Here we examine the role of palladin during Listeria monocytogenes infections in order to tease out novel functions of palladin. We show that
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Legionella pneumophila (Lp) exhibits different morphologies with varying degrees of virulence. Despite their detection in environmental sources of outbreaks and in respiratory tract secretions and lung autopsies from patients, the filamentous morphotype of Lp remains poorly studied. We previously demonstrated
Satoko Sakamoto et al.
PLoS biology, 16(9), e2004874-e2004874 (2018-09-27)
Formin is one of the two major classes of actin binding proteins (ABPs) with nucleation and polymerization activity. However, despite advances in our understanding of its biochemical activity, whether and how formins generate specific architecture of the actin cytoskeleton and
Ivana Viktorinová et al.
PLoS genetics, 13(11), e1007107-e1007107 (2017-11-28)
Symmetry breaking is involved in many developmental processes that form bodies and organs. One of them is the epithelial rotation of developing tubular and acinar organs. However, how epithelial cells move, how they break symmetry to define their common direction
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