SMB00915

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester)

≥95% (HPLC)

• Synonym(e): BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester), (3α,5β,12β)-3,12-dihydroxy-11-oxo-cholan-24-oic-acid methyl ester
• Empirische Formel (Hill-System): C₂₅H₄₀O₅
• CAS-Nummer: 27240-87-5
• Molekulargewicht: 420.58
• UNSPSC-Code: 41141802
• NACRES: NA.25

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: white to beige
• mp (Schmelzpunkt): 153.5—154.5 °C
• Löslichkeit: chloroform: 20 mg/mL, colorless to light yellow
• Lagertemp.: 2-8°C
• SMILES String: O=C(OC)CCC(C)C1CCC2C3CCC4CC(O)CCC4(C)C3C(=O)C(O)C12C

Beschreibung

Allgemeine Beschreibung

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) is a more potent analog of microbiome metabolite BAA485 (12-oxolithocholic acid) that activates the Pyrin inflammasome in myeloid and intestinal epithelial cells. BAA473 potently induces secretion of IL1β and IL18 in LPS-primed PBMCs and THP-1 cells.

Bile acids, natural steroid amphipathic compounds formed through cholesterol oxidation in the liver, play a crucial role in regulating lipid metabolism. They facilitate the digestion, absorption, and transport of lipids, lipid-soluble vitamins, and related molecules in the gastrointestinal tract. These bile acids also impact various aspects of cholesterol, glucose, and energy balance.

Anwendung

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) finds application in metabolomics, biochemical and microbiome research.

Leistungsmerkmale und Vorteile

• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Sonstige Hinweise

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable