PZ0187

Begacestat

≥98% (HPLC)

• Synonym(e): 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2- (trifluoromethyl)propyl] thiophene-2-sulfonamide, GSI-953
• Empirische Formel (Hill-System): C₉H₈ClF₆NO₃S₂
• CAS-Nummer: 769169-27-9
• Molekulargewicht: 391.74
• MDL-Nummer: MFCD18782675
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329823761
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to tan
• Löslichkeit: DMSO: ≥15 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: OC[C@@H](NS(=O)(=O)c1ccc(Cl)s1)C(C(F)(F)F)C(F)(F)F
• InChI: 1S/C9H8ClF6NO3S2/c10-5-1-2-6(21-5)22(19,20)17-4(3-18)7(8(11,12)13)9(14,15)16/h1-2,4,7,17-18H,3H2/t4-/m1/s1
• InChIKey: PSXOKXJMVRSARX-SCSAIBSYSA-N
• Angaben zum Gen: human ... APH1A(51107) , APH1B(83464) , NCSTN(23385) , PSEN1(5663) , PSEN2(5664) , PSENEN(55851)

Beschreibung

Biochem./physiol. Wirkung

Begacestat (GSI-953) is a selective γ-secretase inhibitor that selectively inhibits cleavage of APP over Notch.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable