NCSTN
nicastrin
Synonymes:
APH2
Espèce(s):
Human NCSTN (23385), Mouse Ncstn (59287), Rat Ncstn (289231), Zebrafish ncstn (494449), cow NCSTN (514929), Horse NCSTN (100058515), domestic cat NCSTN (101090586), dog NCSTN (488638), chicken NCSTN (426905), domestic guinea pig Ncstn (100731821) ...Plus
ID UniProtKB:
ID du gène:
- Human(23385) Summary: This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(59287) nicastrin
- Rat(289231) nicastrin
- Zebrafish(494449) nicastrin
- cow(514929) nicastrin
- Horse(100058515) nicastrin
- domestic cat(101090586) nicastrin
- dog(488638) nicastrin
- chicken(426905) nicastrin
- domestic guinea pig(100731821) nicastrin
- naked mole-rat(101718052) nicastrin
- sheep(101120457) nicastrin
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-Nicastrin antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
microarray
western blot
western blot
Anti-Nicastrin Antibody, ascites fluid, clone 9C3, Chemicon®,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-NCSTN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-NCSTN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-Nicastrin (ab1) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot