P2363

Protein Kinase G II from rat

>90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, solution

• Synonym(e): Protein Kinase, 3′,5′-Cyclic GMP Dependent from rat
• MDL-Nummer: MFCD03444648
• UNSPSC-Code: 41106305
• NACRES: NA.32

Eigenschaften

• Rekombinant: expressed in baculovirus infected Sf9 cells
• Qualitätsniveau: 200
• Assay: >90% (SDS-PAGE)
• Form: solution
• Spezifische Aktivität: ~0.7 U/mg
• UniProt-Hinterlegungsnummer: Q64595
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Angaben zum Gen: rat ... Prkg2(25523)

Beschreibung

Allgemeine Beschreibung

Protein kinase, cGMP-dependent, type II (PRKG2), also known as type II cGMP-dependent protein kinase (cGK), is encoded by the gene mapped to human chromosome 4q13.1–q21.1.

Biochem./physiol. Wirkung

Protein kinase, cGMP-dependent, type II (PRKG2) is implicated in the regulation of intestinal fluid balance in man. The encoded protein plays an essential role in proliferative to hypertrophic transition of growth plate chondrocytes during endochondral ossification. Loss of PRKG2 function is associated with the development of renal cysts, intellectual disability and speech defect. In rodent and bovine models, deletion of the gene leads to dwarfism.

Einheitendefinition

One unit will phosphorylate one μmole of VASPtide (RRKVSKQE) per minute at pH 7.4

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable