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M2949

Sigma-Aldrich

MDL 72527

≥98% (HPLC)

Synonym(e):

CPC-200, MDL-72527DA, N,N′-Bis(2,3-butadienyl)-1,4-butanediamine dihydrochloride, N1,N4-Bis(2,3-butadienyl)-1,4-butanediamine hydrochloride

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About This Item

Empirische Formel (Hill-System):
C12 H20 N2·2 HCl
CAS-Nummer:
93565-01-6
Molekulargewicht:
265.22
MDL-Nummer:
MFCD13152261
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329817958
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to brown

Löslichkeit

H2O: 15 mg/mL, clear

Lagertemp.

room temp

SMILES String

Cl.Cl.C=C=CCNCCCCNCC=C=C

InChI

1S/C12H20N2.2ClH/c1-3-5-9-13-11-7-8-12-14-10-6-4-2;;/h5-6,13-14H,1-2,7-12H2;2*1H

InChIKey

ITVRWVVFVHINOH-UHFFFAOYSA-N

Verwandte Kategorien

Biochem./physiol. Wirkung

MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO).
MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
034M4704V
080M4711

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Agmatin -sulfat (Salz) ≥97%, powder

Sigma-Aldrich

A7127

Agmatin -sulfat (Salz)

Chlorhexidin ≥99.5%

Sigma-Aldrich

282227

Chlorhexidin

Spermin ≥97%

Sigma-Aldrich

S3256

Spermin

Gelatine aus Rinderhaut Type B, powder, BioReagent, suitable for cell culture

Sigma-Aldrich

G9391

Gelatine aus Rinderhaut

Enzo Agostinelli et al.
Biochemical and biophysical research communications, 340(3), 840-844 (2005-12-29)
MDL 72527 was considered a selective inhibitor of FAD-dependent polyamine oxidases. In the present communication, we demonstrate that MDL 72527 inactivates bovine serum amine oxidase, a copper-containing, TPQ-enzyme, time-dependently at 25 degrees C. In striking contrast, the enzyme remained active
Andrea Bellelli et al.
Biochemical and biophysical research communications, 322(1), 1-8 (2004-08-18)
Spermine oxidase (SMO) is a recently described flavoenzyme belonging to the class of polyamine oxidases (PAOs) and participating in the polyamine metabolism in animal cells. In this paper we describe the expression, purification, and characterization of the catalytic properties of
Yoshiko Mitsuya et al.
Journal of plant physiology, 164(6), 785-793 (2006-08-03)
In a previous work, we identified a Cys(2)/His(2)-type zinc-finger transcription repressor, (ZFT1), that functions in a spermine-mediated signal transduction pathway in tobacco plants. Database search disclosed the presence of another Cys(2)/His(2)-type zinc-finger protein ZFP1 (accession number AAC06243) in tobacco plants.
Enzo Agostinelli et al.
International journal of oncology, 29(4), 947-955 (2006-09-12)
The in situ formation of cytotoxic metabolites by an enzyme-catalyzed reaction is a recent approach in cancer therapy. The present results show that multidrug-resistant human colon adenocarcinoma cells (LoVo) are significantly more sensitive than corresponding wild-type cells to hydrogen peroxide
Francine Gossé et al.
International journal of oncology, 29(2), 423-428 (2006-07-06)
Apple procyanidins have chemopreventive properties in a model of colon cancer, they affect intracellular signalling pathways, and trigger apoptosis in a human adenocarcinoma-derived metastatic cell line (SW620). In the present study we investigated relationships between procyanidin-induced alterations in polyamine metabolism
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