K3761

KT 5720

≥98% (HPLC), powder

• Synonym(e): KT 5720
• Empirische Formel (Hill-System): C₃₂H₃₁N₃O₅
• CAS-Nummer: 108068-98-0
• Molekulargewicht: 537.61
• MDL-Nummer: MFCD00132118
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24896235
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: microbial
• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to faint yellow
• Löslichkeit: methanol: 5 mg/mL
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: CCCCCCOC([C@@]1(O)C[C@@]2([H])N3C(C=CC=C4)=C4C5=C3C6=C(C(C=CC=C7)=C7N6[C@]1(C)O2)C8=C5C(NC8)=O)=O
• InChI: 1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1
• InChIKey: ZHEHVZXPFVXKEY-IKZDWWSZSA-N

Beschreibung

Anwendung

KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in α-MSH-activated B16-F0 cells and on COX-2 stimulation of tumor-associated Vascular endothelial growth factor (VEGF) expression.

Biochem./physiol. Wirkung

Specific, cell-permeable inhibitor of protein kinase A (PKA). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK).

Leistungsmerkmale und Vorteile

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable