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I2753

Sigma-Aldrich

Inosine 3′:5′-cyclic monophosphate sodium salt

≥98%

Synonym(e):

cIMP

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About This Item

Lineare Formel:
C10H10N4O7PNa
CAS-Nummer:
41092-64-2
Molekulargewicht:
352.17
MDL-Nummer:
MFCD00057137
UNSPSC-Code:
41106305
PubChem Substanz-ID:
24896007
NACRES:
NA.51

Qualitätsniveau

200

Assay

≥98%

Form

powder

Lagertemp.

−20°C

SMILES String

[Na].OC1C2OP(O)(=O)OCC2OC1n3cnc4C(=O)N=CNc34

InChI

1S/C10H11N4O7P.Na.H/c15-6-7-4(1-19-22(17,18)21-7)20-10(6)14-3-13-5-8(14)11-2-12-9(5)16;;/h2-4,6-7,10,15H,1H2,(H,17,18)(H,11,12,16);;

InChIKey

XIUBZBACWHALEW-UHFFFAOYSA-N

Anwendung

Inosine 3′:5′-cyclic monophosphate (cIMP) is used in studies that compare the substrate specificity and activity of cyclic purines, including the 3′,5′-cyclic monophosphates cAMP and cGMP.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Daisuke Okada et al.
Biochemistry, 41(30), 9672-9679 (2002-07-24)
The effects of cGMP binding on the catalytic activity of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) are unclear because cGMP interacts with both allosteric and catalytic sites specifically. We studied the effects of cGMP on the hydrolysis of a fluorescent substrate analogue
Adam K Jagielski et al.
Archives of biochemistry and biophysics, 404(2), 186-196 (2002-07-31)
The effects of extracellular purinergic agonists and their breakdown products on glucose and glutamine synthesis in rabbit kidney-cortex tubules incubated with aspartate + glycerol or alanine + glycerol + octanoate were investigated. A rapid extracellular degradation of ATP was accompanied
Riegel et al.
The Journal of experimental biology, 201 (Pt 24), 3411-3418 (1998-11-18)
External application of the 3',5'-cyclic monophosphates of inosine, cytidine, uridine and thymidine stimulated the fluid secretion rate (FSR) of Malpighian tubules isolated from Drosophila melanogaster. The evidence suggested that the cyclic nucleotides acted intracellularly in some capacity. Receptors of the
M S Shapiro et al.
Biophysical journal, 78(5), 2307-2320 (2000-04-25)
In vertebrate olfactory receptors, cAMP produced by odorants opens cyclic nucleotide-gated (CNG) channels, which allow Ca(2+) entry and depolarization of the cell. These CNG channels are composed of alpha subunits and at least two types of beta subunits that are
R C Ganassin et al.
Journal of cellular physiology, 160(3), 409-416 (1994-09-01)
The influence of inosine on DNA synthesis by Chinook salmon embryo cells (CHSE-214) was investigated because previously cell number was shown to increase from six- to thirtyfold if inosine was added to the basal medium (L-15) supplemented with either dialyzed
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