G6129

Guanosin-3′,5′-cyclophosphat Natriumsalz

≥99% (HPLC), powder

• Synonym(e): 3′,5′-Cyclisches GMP Mononatriumsalz, 3′,5′-cGMP-Na, Cyclisches GMP, cGMP
• Empirische Formel (Hill-System): C₁₀H₁₁N₅NaO₇P
• CAS-Nummer: 40732-48-7
• Molekulargewicht: 367.19
• Beilstein: 6467425
• EG-Nummer: 255-056-0
• MDL-Nummer: MFCD00038424
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24895245
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥99% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: H₂O: 50 mg/mL
• Lagertemp.: −20°C
• SMILES String: [Na+].NC1=Nc2c(ncn2[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C(=O)N1
• InChI: 1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• InChIKey: KMPIYXNEROUNOG-GWTDSMLYSA-M

Beschreibung

Biochem./physiol. Wirkung

An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases and PKA & PKG pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)