F7876

Folsäure

≥97%

• Synonym(e): PteGlu, Pteroyl-L-glutaminsäure, Vitamin M
• Empirische Formel (Hill-System): C₁₉H₁₉N₇O₆
• CAS-Nummer: 59-30-3
• Molekulargewicht: 441.40
• Beilstein: 100781
• EG-Nummer: 200-419-0
• MDL-Nummer: MFCD00079305
• UNSPSC-Code: 12352106
• eCl@ss: 34058014
• PubChem Substanz-ID: 57654192
• NACRES: NA.79

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Assay: ≥97%
• Form: powder
• Methode(n): HPLC: suitable
• Farbe: faint orange to dark orange-yellow; faint yellow to dark yellow
• mp (Schmelzpunkt): >285 °C
• Lagertemp.: room temp
• SMILES String: NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
• InChI: 1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
• InChIKey: OVBPIULPVIDEAO-LBPRGKRZSA-N

Beschreibung

Anwendung

Folic acid has been used:

• to induce acute kidney injury in mice
• as a supplement to cultivate MCF-7 breast cancer cells.
• to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles

Biochem./physiol. Wirkung

Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)