D1916

5,6-Dichlorbenzimidazol 1-β-D-Ribofuranosid

≥98% (HPLC), powder, RNA synthesis inhibitor

• Synonym(e): 5,6-Dichlor-1-β-D-ribofuranosylbenzimidazol, DRB
• Empirische Formel (Hill-System): C₁₂H₁₂Cl₂N₂O₄
• CAS-Nummer: 53-85-0
• Molekulargewicht: 319.14
• Beilstein: 39123
• MDL-Nummer: MFCD00036785
• UNSPSC-Code: 12352200
• eCl@ss: 32151902
• PubChem Substanz-ID: 24278361
• NACRES: NA.77

Eigenschaften

• product name: 5,6-Dichlorbenzimidazol 1-β-D-Ribofuranosid,
• Form: powder
• Qualitätsniveau: 200
• Lagertemp.: −20°C
• SMILES String: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23
• InChI: 1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
• InChIKey: XHSQDZXAVJRBMX-DDHJBXDOSA-N
• Angaben zum Gen: human ... CSNK2A1(1457) , CSNK2B(1460)

Beschreibung

Anwendung

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:

• as an inhibitor of RNA polymerase II in mouse melanoma cells
• for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines
• in the inhibition of interleukin-2 gene transcription in Jurkat cells

Biochem./physiol. Wirkung

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.

Inhibitor von RNA-Synthese; verursacht vorzeitige Termination der Transkription

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable