A4562

5-(N,N-Dimethyl)amiloride hydrochloride

• Synonym(e): 3-Amino-N-(aminoiminoethyl)-5-(dimethylamino)-6-chloropyrazinecarboxamide hydrochloride, DMA
• Empirische Formel (Hill-System): C₈H₁₂ClN₇O · HCl
• CAS-Nummer: 1214-79-5
• Molekulargewicht: 294.14
• MDL-Nummer: MFCD00069207
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278216
• NACRES: NA.77

Eigenschaften

• Form: powder
• Qualitätsniveau: 200
• Lagertemp.: 2-8°C
• SMILES String: Cl.CN(C)c1nc(N)c(nc1Cl)C(=O)\N=C(\N)N
• InChI: 1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H
• InChIKey: IIUPTHVVXMBJMQ-UHFFFAOYSA-N
• Angaben zum Gen: human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) ; mouse ... Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278) ; rat ... Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782) , Slc9a2(24783) , Slc9a3(24784)

Beschreibung

Anwendung

5-(N,N-Dimethyl)amiloride hydrochloride is a selective blocker of Na²/H⁺ antiport. 5-(N,N-Dimethyl)amiloride hydrochloride has been investigated for its ability to reduce inflammatory pain.

Biochem./physiol. Wirkung

Selective blocker of Na⁺/H⁺ antiport; IC₅₀ = 6.9 μM.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable