17849

Enrofloxacin

≥99.0%

• Synonym(e): Baytril
• Empirische Formel (Hill-System): C₁₉H₂₂FN₃O₃
• CAS-Nummer: 93106-60-6
• Molekulargewicht: 359.39
• Beilstein: 5307824
• MDL-Nummer: MFCD00792463
• UNSPSC-Code: 41116105
• PubChem Substanz-ID: 329751571
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥99.0%; 99.0-101.0% (dried substance)
• Form: powder or crystals
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria
• Wirkungsweise: DNA synthesis | interferes; enzyme | inhibits
• SMILES String: CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4
• InChI: 1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)
• InChIKey: SPFYMRJSYKOXGV-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: fluoroquinolone

Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.

Anwendung

Enrofloxacin has been used:

• to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells
• to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)
• as an analyte in a chemiluminescence reagent system

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H317,H334
• P-Sätze: P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352
• Gefahreneinstufungen: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)