341305

Fasentin

• Synonym(e): Fasentin, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide, Glucose Transporter Inhibitor, Glucose Transporter Inhibitor, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
• Empirische Formel (Hill-System): C₁₁H₉ClF₃NO₂
• CAS-Nummer: 392721-37-8
• Molekulargewicht: 279.64
• MDL-Nummer: MFCD01001285
• UNSPSC-Code: 12352200
• NACRES: NA.54

Eigenschaften

• Assay: ≥95% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: off-white
• Löslichkeit: DMSO: 20 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• InChI: 1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)
• InChIKey: GNYIJZMBLZXJEJ-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable oxobutananilide compound that is predicted to interact with Glut (Glucose Transporter) at an intracellular site based on a virtual docking study and shown to inhibit Glut-mediated cellular glucose uptake (50% and 80% inhibition of 2-deoxy-D-glucose uptake in Glut1- and Glut4-overexpressing L6 myoblasts, respectively, at 300 µM). Fas-resistant cell lines that are made Fas-responsive upon medium glucose deprivation are also shown to be sensitized by Fasentin to Fas-mediated cell death (ED₅₀ = 35 µM in PPC-1 cultures), while cells that remain Fas-resistant upon glucose deprivation, e.g. DU145, are shown not to be sensitized by Fasentin to Fas-mediated death.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -2°C.

Sonstige Hinweise

Wood, T.E., et al. 2008. Mol. Cancer Ther.7, 3546
Schimmer, A.D., et al. 2006. Cancer Res.66, 2367.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable