- Total synthesis of (+)-cyperolone.
Total synthesis of (+)-cyperolone.
Organic letters (2012-02-14)
Philipp Klahn, Alexander Duschek, Clémence Liébert, Stefan F Kirsch
PMID22324453
ABSTRACT
The total synthesis of (+)-cyperolone, an eudesmane-derived sesquiterpenoid from Cyperus rotundus, is described. The de novo synthesis was accomplished via a 15 step sequence starting from (R)-(-)-carvone. The synthetic route features a platinum-catalyzed cycloisomerization to rapidly construct the bicyclic core from a 3-silyloxy-1,5-enyne intermediate.
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(+)-Carvone, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland