16023AST
Astec® CHIROBIOTIC® T2 Chiral (5 μm) HPLC Columns
L × I.D. 15 cm × 4.6 mm, HPLC Column
Sinonimo/i:
Astec CHIROBIOTIC T2 column
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About This Item
Codice UNSPSC:
41115700
eCl@ss:
32110501
NACRES:
SB.52
Prodotti consigliati
product name
Astec® Chirobiotic® T2 Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Materiali
stainless steel column
agenzia
suitable for USP L63
Descrizione
HPLC column
Nome Commerciale
Astec®
Confezionamento
pkg of 1 ea
Produttore/marchio commerciale
Astec®
Parametri
0-45 °C temperature
241 bar pressure (3500 psi)
tecniche
HPLC: suitable
LC/MS: suitable
Lungh. × D.I.
15 cm × 4.6 mm
Matrice
high-purity silica gel particle platform
fully porous particle
Dimensione particelle
5 μm
Dimensione pori
200 Å
operating pH range
3.8-6.8
Tecnica di separazione
chiral
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Descrizione generale
CHIROBIOTIC® T and T2 have teicoplanin as the chiral selector. They offer unique selectivity for a number of classes of molecules, specifically underivatized α, β, γ and cyclic amino acids, N-derivatized amino acids, hydroxy-carboxylic acids, acidic compounds including carboxylic acids and phenols, small peptides, neutral aromatic analytes and cyclic aromatic and aliphatic amines. Separations normally obtained on a chiral crown ether or ligand exchange-type CSPs are also possible on the CHIROBIOTIC® T and T2, but in much simpler mobile phases, like water-alcohol. In addition, all of the known beta-blockers (amino alcohols), and dihydrocoumarins have been resolved. CHIROBIOTIC® T and T2 differ in their bonding chemistry and the pore size of the support particle, giving them different selectivity and preparative capacity.
- Bonded phase: Teicoplanin
- Operating pH range: 3.8 - 6.8
- Particle diameter: 5, 10 or 16 μm
- Pore size: 100 Å (CHIROBIOTIC® T) or 200 Å (CHIROBIOTIC® T2)
Applicazioni
- High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: This research employs the Astec® CHIROBIOTIC T2 Chiral HPLC Column for the enantioseparation of various amino acids. The study highlights the column′s effectiveness in separating complex chiral molecules, demonstrating its application in the analysis of amino acids and related compounds in chemical and pharmaceutical research (Berkecz et al., 2009).
Note legali
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
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Chromatography Liquid Chiral Separations
Xiao, T.L., et al.
Encyclopedia of Separation Science, 1-15 (2000)
Chromatographic Separations and Analysis: Macrocyclic Glycopeptide Chiral Stationary Phases
Berthod, A.
Comprehensive Chirality, 8, 227-262 (2012)
Ping Sun et al.
Journal of molecular structure, 890(1-3), 75-80 (2008-11-12)
A high performance liquid chromatographic method using macrocyclic glycopeptide chiral stationary phases (CSPs) was used to separate enantiomers of seven ruthenium(II) polypyridyl complexes. Among the five different CSPs, the Chirobiotic T2 was most effective and baseline separated all complexes. All
Chris Hamman et al.
Journal of chromatography. A, 1305, 310-319 (2013-07-31)
A rapid screening method to identify the best conditions for chiral separations is described. We analyzed a representative set of 80 racemic compounds against 25 different chiral stationary phases with three different mobile phases to identify the combination of columns
Sarangan Ravichandran et al.
Journal of chromatography. A, 1269, 218-225 (2012-08-25)
The enantioselective separations of the chiral oxazaphosphorines (R,S)-ifosfamide (IF), (R,S)-2-N-dechloroethyl-IF (2-DCE-IF) and (R,S)-3-N-dechloroethyl-IF (3-DCE-IF) were achieved on teicoplanin-based chiral stationary phase using isopropanol:methanol (60:40, v/v) as the mobile phase. Computational models of the teicoplanin and teicoplanin aglycon (TAG) chiral selectors
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