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UC431

Sigma-Aldrich

4-Hydroxymidazolam

≥97% (HPLC), solid

Sinonimo/i:

8-Chloro-6-(2-fluorophenyl)-4-hydroxy-4H-imidazo[1,5a][1,4]bezodiazepine

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About This Item

Formula empirica (notazione di Hill):
C18H13ClFN3O
Numero CAS:
59468-85-8
Peso molecolare:
341.77
Numero MDL:
MFCD00871459
Codice UNSPSC:
12161501
ID PubChem:
24724656
NACRES:
NA.77

product name

4-Hydroxymidazolam,

Forma fisica

solid

Controllo stupefacenti

regulated under CDSA - not available from Sigma-Aldrich Canada

Colore

white to off-white

Punto di fusione

186-187 °C

Temperatura di conservazione

2-8°C

Stringa SMILE

FC(C=CC=C1)=C1C2=NC(O)C3=CN=C(C)N3C4=C2C=C(Cl)C=C4

InChI

1S/C18H13ClFN3O/c1-10-21-9-16-18(24)22-17(12-4-2-3-5-14(12)20)13-8-11(19)6-7-15(13)23(10)16/h2-9,18,24H,1H3
ZYISITHKPKHPKG-UHFFFAOYSA-N

Applicazioni

4′-Hydroxymidazolam can be used in cell biology studies. It can also be used for studying cell signaling and neuroscience.

Azioni biochim/fisiol

4′-Hydroxymidazolam is the minor hydroxylated metabolite of Midazolam (MDZ). The product contributes in the pharmacological impact of MDZ.
CYP3A4 metabolite of midazolam.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

G7017

β-Glucuronidasi

C B Eap et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 802(2), 339-345 (2004-03-17)
Midazolam is a widely accepted probe for phenotyping cytochrome P4503A. A gas chromatography-mass spectrometry (GC-MS)-negative chemical ionization method is presented which allows measuring very low levels of midazolam (MID), 1-OH midazolam (1OHMID) and 4-OH midazolam (4OHMID), in plasma, after derivatization
Chin B Eap et al.
European journal of clinical pharmacology, 60(4), 237-246 (2004-04-29)
We investigated whether the oral administration of a low dose (75 micro g) of midazolam, a CYP3A probe, can be used to measure the in vivo CYP3A activity. Plasma concentrations of midazolam, 1'OH-midazolam and 4'OH-midazolam were measured after the oral
J Martens et al.
Journal of chromatography. B, Biomedical sciences and applications, 692(1), 95-100 (1997-04-25)
A method for the quantitation of midazolam and its metabolites 1-hydroxymidazolam and 4-hydroxymidazolam from human serum capable of monitoring concentrations achieved under therapeutic conditions is presented. The substances were extracted under basic conditions with toluene and the hydroxy metabolites transformed
Wilson Z Shou et al.
Rapid communications in mass spectrometry : RCM, 16(17), 1613-1621 (2002-08-31)
Ultrafast liquid chromatography/tandem mass spectrometry (LC/MS/MS) bioanalysis was demonstrated with the use of packed silica columns operated under elevated flow rates. A special effort has been made to achieve ultrafast analysis without sacrificing chromatographic resolution. Two multiple analyte/metabolites assays, (1)
Bettina Link et al.
Rapid communications in mass spectrometry : RCM, 21(9), 1531-1540 (2007-04-06)
Midazolam (MDZ), a short-acting benzodiazepine, is a widely accepted probe drug for CYP3A phenotyping. Published methods for its analysis have used either therapeutic doses of MDZ, or, if employing lower doses, were mostly unable to quantify the two hydroxy metabolites.
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