Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

SML0572

Sigma-Aldrich

Valspodar

≥98% (HPLC)

Sinonimo/i:

6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D, Amdray, PSC833, [3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C63H111N11O12
Numero CAS:
121584-18-7
Peso molecolare:
1214.62
Numero MDL:
MFCD00907207
Codice UNSPSC:
12161501
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

desiccated

Colore

white to beige

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

InChI

1S/C63H111N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-52H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46+,47+,49+,50+,51+,52+/m1/s1
YJDYDFNKCBANTM-QCWCSKBGSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Applicazioni

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.

Azioni biochim/fisiol

Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 9

1 of 9

Rhodamine 123 BioReagent, for fluorescence, ≥85% (HPLC)

Sigma-Aldrich

83702

Rhodamine 123

Cyclosporin A BioReagent, from Tolypocladium inflatum, for molecular biology, ≥95%

Sigma-Aldrich

C1832

Cyclosporin A

Concanamycin A ≥70% (HPLC)

Sigma-Aldrich

C9705

Concanamycin A

Quinidine anhydrous

Sigma-Aldrich

Q3625

Quinidine

Lucifer Yellow CH dilithium salt fluorescent stain

Sigma-Aldrich

L0259

Lucifer Yellow CH dilithium salt

Calceina-AM Small Package (20 X 50 μg ), ≥95.0% (HPLC)

Sigma-Aldrich

56496

Calceina-AM

Cyclosporin A from Tolypocladium inflatum, ≥95% (HPLC), solid

Sigma-Aldrich

C3662

Cyclosporin A

Calceina-AM suitable for fluorescence, BioReagent, ≥95.0% (HPLC)

Sigma-Aldrich

17783

Calceina-AM

Cyclosporin A 97.0-101.5% (on dried basis)

Sigma-Aldrich

30024

Cyclosporin A

Kohjiro Nagao et al.
Biochimica et biophysica acta, 1831(2), 398-406 (2012-11-17)
ATP-binding cassette protein A1 (ABCA1) plays a key role in generating high-density lipoprotein (HDL). However, the detailed mechanism of HDL formation remains unclear; in order to reveal it, chemicals that specifically block each step of HDL formation would be useful.
Benjamin L Emmink et al.
Gastroenterology, 141(1), 269-278 (2011-04-05)
Stem cells of normal tissues have resistance mechanisms that allow them to survive genotoxic insults. The stem cell-like cells of tumors are defined by their tumor-initiating capacity and may have retained these resistance mechanisms, making them resistant to chemotherapy. We
Lynae M Brayboy et al.
Fertility and sterility, 100(5), 1428-1435 (2013-08-21)
To determine the multidrug-resistant transporter (MDR) activity in oocytes and their potential role in oocyte susceptibility to chemotherapy. Experimental laboratory study. University and academic center for reproductive medicine. Women with eggs retrieved for intracytoplasmic sperm injection cycles and adult female
Ziyad Binkhathlan et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(1), 142-148 (2012-03-01)
Co-administration of P-glycoprotein (P-gp) inhibitors such as cyclosporine A (CyA) and its analogue valspodar with doxorubicin (DOX) can result in diminished clearance of DOX, leading to accentuated toxicity. The purpose of this study was to evaluate whether the effect of
Jonathan E Kolitz et al.
Blood, 116(9), 1413-1421 (2010-06-05)
Cancer and Leukemia Group B 19808 (CALGB 19808) is the only randomized trial of a second-generation P-glycoprotein (Pgp) modulator in untreated patients with acute myeloid leukemia (AML) younger than age 60 years. We randomly assigned 302 patients to receive induction
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.