B5399

(±)-Baclofen

≥98% (HPLC), solid

• Sinonimo/i: (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
• Formula empirica (notazione di Hill): C₁₀H₁₂ClNO₂
• Numero CAS: 1134-47-0
• Peso molecolare: 213.66
• Numero CE: 214-486-9
• Numero MDL: MFCD00055143
• Codice UNSPSC: 12352200
• ID PubChem: 24278146
• NACRES: NA.32

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: solid
• Colore: white to very faintly yellow
• Solubilità: 1 M HCl: 50 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: ClC1=CC=C(C(CN)CC(O)=O)C=C1
• InChI: 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14); KPYSYYIEGFHWSV-UHFFFAOYSA-N
• Informazioni sul gene: human ... GABBR1(2550) , GABBR2(9568) ; rat ... Gabbr1(81657) , Gabra2(29706)

Descrizione

Applicazioni

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABA_B receptor agonist:

• as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
• to test its effects on in vivo motor function tests and performance of mutant mice
• to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
• to test its effect in reducing dendritic excitability in Purkinje neurons

Azioni biochim/fisiol

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABA_B) agonist, baclofen may be involved in the potentiation of dendritic potassium K⁺ channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).

GABA_B receptor agonist; skeletal muscle relaxant; antispastic agent.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 3 Oral
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges