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Merck
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Key Documents

Altri documenti

G014

Sigma-Aldrich

S(−)-Baclofen hydrochloride

≥98% (HPLC), solid

Sinonimo/i:

S(–)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C10H12ClNO2 · HCl
Numero CAS:
63701-56-4
Peso molecolare:
250.12
Numero MDL:
MFCD00078580
Codice UNSPSC:
12352200
ID PubChem:
24895007
NACRES:
NA.32

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Attività ottica

[α]28/D −2.2°, c = 0.9 in methanol(lit.)

Colore

white

Solubilità

DMSO: >20 mg/mL

Stringa SMILE

Cl[H].NC[C@@H](CC(O)=O)c1ccc(Cl)cc1

InChI

1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m1./s1
WMNUVYYLMCMHLU-DDWIOCJRSA-N

Azioni biochim/fisiol

S(−)-Baclofen hydrochloride is a less active enantiomer of baclofen.

Altre note

Same enantiomer as S(+)-baclofen free base.

Codice della classe di stoccaggio

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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R Paredes et al.
Psychopharmacology, 97(3), 358-364 (1989-01-01)
The behavior effects of racemic baclofen and the R and S enantiomers were studied in order to determine whether the stereospecificity found in receptor binding studies also applies to the behavioral actions of the drug. Racemic and R-baclofen inhibited sexual
Y G Hong et al.
European journal of pharmacology, 196(3), 267-275 (1991-04-24)
In a previous study it was found that i.t. administration of L-baclofen decreased arterial pressure and heart rate while D-baclofen differentially increased arterial pressure. The objective of the present study was to determine which of these effects was blocked by
E Falch et al.
Journal of neurochemistry, 47(3), 898-903 (1986-09-01)
The affinities of a number of analogues of gamma-aminobutyric acid (GABA) for GABAA and GABAB receptor sites and GABA uptake were studied using rat brain membrane preparations. Studies on the (S)-(+)- and (R)-(-)-isomers of baclofen, 3-hydroxy-4-aminobutyric acid (3-OH-GABA), and 4,5-dihydromuscimol
B Witczuk et al.
Polish journal of pharmacology and pharmacy, 32(2), 187-196 (1980-03-01)
Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to be 4.2-9.2-fold as effective as the S(-) one

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